高雄醫學大學醫學研究所 - 橫山一成

姓名：橫山一成博士（Kazushige K. Yokoyama, Ph.D.）現任：高雄醫學大學醫學研究所專任教授 Tel： 07-3121101轉2729 Email：kazu@kmu.edu.tw Web: http://kazu.dlearn.kmu.edu.tw/
學歷 Education	1969 - 1973 B.S., Department of Agriculture, Shizuoka University, Japan 1974 - 1976 M.A., Department of Science, University of Tokyo, Japan 1976 - 1979 Ph.D., Department of Science, University of Tokyo, Japan

經歷 Crossed Appointments	1979 - 1983 Postdoctoral Fellow, Albert Einstein College of Medicine, USA 1883 - 1985 Junior Research Scientist (=Assistant Professor), City of Hope, Duarte, California, USA 1985 - 1988 Researcher, Laboratory of Molecular Genetics, RIKEN, Tsukuba, Japan 1987 - 1991 Frontier Research Program (Chromosome), RIKEN, Tsukuba, Japan 1990 Exchanging Researcher, Pasteur Institute, Paris Cedex, France 1989 - 1990 Human Genome Project in RIKEN, RIKEN, Tsukuba, Japan 1994 - 2000 Head of DNA Bank, Gene Bank, RIKEN, Tsukuba, Japan 2001 - 2009 Head of Gene Engineering Division, BioResource Center, RIKEN, Tsukuba, Japan 2001 - 2009 Adjunct professor of the University of Tennessee, Graduate School of Medicine, Knoxville, TN, USA 2009 - present Adjunct Senior Researcher of The University of Tokyo, Tokyo, Japan 2009 - present Adjunct Senior Researcher of RIKEN, BioResource Center, Tsukuba, Japan 2007 - present Adjunct Senior Researcher of Tsukuba University, Tsukuba, Japan 2009 - present Professor, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

專長 Highlights of Qualifications	Molecular Biology of Stem Cells and Cancer Stem Cells Epigenesis and Reprogramming of iPS Cells Human Gene Therapy Transcription and Chromatin

研究方向 Research Interests	Chromatin regulation on self-renewal and differentiation Oxidative stress and anti-oxidation for replicative senescence, stemness and pluripotency Human gene therapy (virus, small molecules and nucleic acids)

執行計畫 Grants	科技部計畫：（1）101-2320-B-037 -047 -MY3 2012/08/01~ 2015/07/31 藉由轉錄因子JDP2研究Wnt訊息傳遞與染色質調節來進行小腦顆粒性細胞在腫瘤生成的探討（2）103-2314-B-037 -063 – 2014/08/01~2015/07/31 胃癌腫瘤發生進程中HOXA family調控腫瘤微環境之研究--人類胃黏膜細胞衍生誘導型多能幹細胞（iPSCs）之HOXA基因組受微環境中調控影響其自我再生及多能性之研究(1/2) 國衛院計畫：（1） NHRI-EX104-10416SI) 2015/01/01~2017/12/31 探討AhR-Nrf2基因調控途徑之交互作用對於調節幹細胞活性氧化物平衡時所扮演的角色高醫校內計畫：（1） KMU-DT103001 103/05/01~ 104/07/31 AP-1抑制JDP2動物模式在髓母細胞瘤的研究（2） KMU-TP103A04 103/08/01~ 104/07/31 經AhR-Jdp2-Nrf2 網絡來研究低氧環境壓力所誘發之活性含氧物體內平衡作用（3） KMU-TP103G03 103/08/01~ 104/07/31 誘導型多能幹細胞 (iPSCs) 在基因療法與藥物開發之研究

代表著作 Select papers	Selected publication (in Taiwan) Pan, J., Nakade, K., Huang, Y-C., Zhu Z-W., Masuzaki, S., Hasegawa, H., Murata, T., Yoshiki, A., Yamaguchi, N., Lee, C-H., Yang, W-C., Tsai, E-M., Obata, Y., and Yokoyama, K.; Suppression of cell cycle progression by Jun dimerization protein 2 (JDP2) involves down-regulation of cyclin A2. Oncogene 29, 6245-6256 (2010). Wang, S-W., Lee. J-K., Ku C-C., Chiou S-S., Lin S. C-L., Ho M-F., Wu D-C., and Yokoyama, K.: Jun dimerization 2 in oxygen restriction; control of senescence. Curr. Pharm. Design 17, 2278-2289 (2011) (cover). Maruyama, K., Fukasaka, M., Vandenbon, A., Saitoh, T., Kawasaki, T., Kondo, T., Yokoyama K., Kidoya, H., Takakura, N., Stanley, D., Takeuchi, O. and Akira, S. The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteroclast and neutrophil differentiation. Immunity 37, 1024-1036 (2012). Wang S-W., Wang, S. S-W., Wu, D-C., Lin Y-C., Ku C-C., Wu, C-C., Chai C-Y., Lee J-N., Tsai, E-M., Lin, S. C-L., Yang, R-C., Ko, Y-C., Yu, H-S., Huo, C., Chuu, C-P., Murayama, Y., Nakamura, Y., Hashimoto, S., Matsushima, K., Jin, C., Lin, C-S., K., Saito, S. and Yokoyama, K.; Androgen receptor-mediated apoptosis in bovine testicular induced pluripotent stem cells in response to phthalate esters. Cell Death & Disease 4, e907 (2013) Tanigawa, S., Lee, C-H., Lin C-S., Ku, C-C., Hasegawa, H., Qin, S., Kawahara, A., Korenori. Y., Qin, S., Miyamori, K., Noguchi, M., Lee, L-H., Lin Y-C., Lin, S. C-L., Nakamura, Y., Jin C., Yamaguchi, N., Eckner, R., Hou, D-X., and Yokoyama, K.: Jun dimerization protein 2 is a novel critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis. Cell Death & Disease 4, e921 (2013). Yokoyama, K., and Kuo Kung-Kai.; Role of chromatin-remodeling factor JDP2 in cellular senescence. Tumor Dormancy and Cellular Quiescence and Senescence. Volume 2, ed. by Hayat, M. A. Springer Science, USA. pp. 101-109 (2014). Fang, L., Wuputra K., Chen D., Li H., Huang, S-K., Jin C., and Yokoyama K.; Environmental-stress-induced chromatin regulation and its heritability. J. Carcinogenesis & Mutagenesis, 5, 156. doi:10.4172/2157-2518.1000156 (2014). Kazunari K. Yokoyama.: Two-hit reprogramming of induced pluripotent stem cells. Occupational Medicine & Health Affairs, in press (2014).