橫山一成 博士 （Kazushige K. Yokoyama, Ph.D.）
現任：高雄醫學大學 醫學研究所 專任教授
Tel： 07-3121101轉2729
Email：kazu@kmu.edu.tw
Web: http://kazu.dlearn.kmu.edu.tw/
學歷
Education
1969 - 1973
B.S., Department of Agriculture, Shizuoka University, Japan
1974 - 1976
M.A., Department of Science, University of Tokyo, Japan
1976 - 1979
Ph.D., Department of Science, University of Tokyo, Japan
經歷
Crossed Appointments
1979 - 1983
Postdoctoral Fellow, Albert Einstein College of Medicine, USA
1883 - 1985
Junior Research Scientist (=Assistant Professor), City of Hope, Duarte, California, USA
1985 - 1988
Researcher, Laboratory of Molecular Genetics, RIKEN, Tsukuba, Japan
1987 - 1991
Frontier Research Program (Chromosome), RIKEN, Tsukuba, Japan
1990
Exchanging Researcher, Pasteur Institute, Paris Cedex, France
1989 - 1990
Human Genome Project in RIKEN, RIKEN, Tsukuba, Japan
1994 - 2000
Head of DNA Bank, Gene Bank, RIKEN, Tsukuba, Japan
2001 - 2009
Head of Gene Engineering Division, BioResource Center, RIKEN, Tsukuba, Japan
2001 - 2009
Adjunct professor of the University of Tennessee, Graduate School of Medicine, Knoxville, TN, USA
2009 - present
Adjunct Senior Researcher of The University of Tokyo, Tokyo, Japan
2009 - present
Adjunct Senior Researcher of RIKEN, BioResource Center, Tsukuba, Japan
2007 - present
Adjunct Senior Researcher of Tsukuba University, Tsukuba, Japan
2009 - present
Professor, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
專長
Highlights of Qualifications
1. Molecular Biology of Stem Cells and Cancer Stem Cells
2. Epigenesis and Reprogramming of iPS Cells
3. Human Gene Therapy
4. Transcription and Chromatin
研究方向
Research Interests
1. Chromatin regulation on self-renewal and differentiation
2. Oxidative stress and anti-oxidation for replicative senescence, stemness and pluripotency
3. Human gene therapy (virus, small molecules and nucleic acids)
執行計畫
Grants
1. 科技部計畫：
（1）101-2320-B-037 -047 -MY3
2012/08/01~ 2015/07/31
藉由轉錄因子JDP2研究Wnt訊息傳遞與染色質調節來進行小腦顆粒性細胞在腫瘤生成的探討
（2）103-2314-B-037 -063 –
2014/08/01~2015/07/31
胃癌腫瘤發生進程中HOXA family調控腫瘤微環境之研究--人類胃黏膜細胞衍生誘導型多能幹細胞（iPSCs）之HOXA基因組受微環境中調控影響其自我再生及多能性之研究(1/2)
2. 國衛院計畫：
（1） NHRI-EX104-10416SI)
2015/01/01~2017/12/31
探討AhR-Nrf2基因調控途徑之交互作用對於調節幹細胞活性氧化物平衡時所扮演的角色
3. 高醫校內計畫：
（1） KMU-DT103001
103/05/01~ 104/07/31
AP-1抑制JDP2動物模式在髓母細胞瘤的研究
（2） KMU-TP103A04
103/08/01~ 104/07/31
經AhR-Jdp2-Nrf2 網絡來研究低氧環境壓力所誘發之活性含氧物體內平衡作用
（3） KMU-TP103G03
103/08/01~ 104/07/31
誘導型多能幹細胞 (iPSCs) 在基因療法與藥物開發之研究
代表著作
Select papers
Selected publication (in Taiwan)
1. Pan, J., Nakade, K., Huang, Y-C., Zhu Z-W., Masuzaki, S., Hasegawa, H., Murata, T., Yoshiki, A., Yamaguchi, N., Lee, C-H., Yang, W-C., Tsai, E-M., Obata, Y., and Yokoyama, K.; Suppression of cell cycle progression by Jun dimerization protein 2 (JDP2) involves down-regulation of cyclin A2. Oncogene 29, 6245-6256 (2010).
2.Wang, S-W., Lee. J-K., Ku C-C., Chiou S-S., Lin S. C-L., Ho M-F., Wu D-C., and Yokoyama, K.: Jun dimerization 2 in oxygen restriction; control of senescence. Curr. Pharm. Design 17, 2278-2289 (2011) (cover).
3.Maruyama, K., Fukasaka, M., Vandenbon, A., Saitoh, T., Kawasaki, T., Kondo, T., Yokoyama K., Kidoya, H., Takakura, N., Stanley, D., Takeuchi, O. and Akira, S. The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteroclast and neutrophil differentiation. Immunity 37, 1024-1036 (2012).
4. Wang S-W., Wang, S. S-W., Wu, D-C., Lin Y-C., Ku C-C., Wu, C-C., Chai C-Y., Lee J-N., Tsai, E-M., Lin, S. C-L.,
Yang, R-C., Ko, Y-C., Yu, H-S., Huo, C., Chuu, C-P., Murayama, Y., Nakamura, Y., Hashimoto, S., Matsushima, K., Jin, C., Lin, C-S., K., Saito, S. and Yokoyama, K.; Androgen receptor-mediated apoptosis in bovine testicular induced pluripotent stem cells in response to phthalate esters. Cell Death & Disease 4, e907 (2013)
5. Tanigawa, S., Lee, C-H., Lin C-S., Ku, C-C., Hasegawa, H., Qin, S., Kawahara, A., Korenori. Y., Qin, S., Miyamori, K., Noguchi, M., Lee, L-H., Lin Y-C., Lin, S. C-L., Nakamura, Y., Jin C., Yamaguchi, N., Eckner, R., Hou, D-X., and Yokoyama, K.: Jun dimerization protein 2 is a novel critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis. Cell Death & Disease 4, e921 (2013).
6. Yokoyama, K., and Kuo Kung-Kai.; Role of chromatin-remodeling factor JDP2 in cellular senescence. Tumor Dormancy and Cellular Quiescence and Senescence. Volume 2, ed. by Hayat, M. A. Springer Science, USA. pp. 101-109 (2014).
7. Fang, L., Wuputra K., Chen D., Li H., Huang, S-K., Jin C., and Yokoyama K.; Environmental-stress-induced chromatin regulation and its heritability. J. Carcinogenesis & Mutagenesis, 5, 156. doi:10.4172/2157-2518.1000156 (2014).
8.Kazunari K. Yokoyama.: Two-hit reprogramming of induced pluripotent stem cells. Occupational Medicine & Health Affairs, in press (2014).