林常申 (Chang-Shen Lin）
現任： 副教授 Associated professor
Tel： 07-3121101 ext 2136-27
Email： csl@kmu.edu.tw
學歷
台大醫學院微生物所博士、陽明微免所碩士、台大植物系學士
Ph.D., Graduate Institute of Microbiology, National Taiwan University (Taipei, Taiwan)
M.S., Graduate Institute of Microbiology and Immunology, National Yang-Ming University (Taipei, Taiwan)
B.S., Department of Botany, National Taiwan University (Taipei, Taiwan)
經歷
國家衛生研究院博士後研究、台大醫學院微生物所博士後研究
Post-doctoral Fellow, National Health Research Institutes (Zhunan, Taiwan)
Post-doctoral Fellow, National Taiwan University (Taipei, Taiwan)
專長
癌症生物學、病毒學
Cancer biology, Virology
研究方向
檳榔致癌機制、癌症抗藥性、腫瘤病毒、基因調控、幹細胞
Carcinogenicity of betel quid, Drug resistance of cancer cells, Tumor viruses, Gene regulation, Stem cell biology
執行計畫
1. 多環芳香烴化合物對肝癌之癌症幹細胞生成的影響 The effects of polycyclic aromatic hydrocarbons on the generation of liver cancer stem-like cells (科技部MOST) 2017/8/1~2020/7/31 主持人 PI
2. 三陰性乳癌細胞中LGR5蛋白參與侵襲與轉移的相關機制探討以及利用磁性輔助配適體快速篩選平台開發抑制LGR5活性之標靶化療配適體 To investigate the malignant role of LGR5 in triple-negative breast cancer and develop LGR5 targeted chemotherapy aptamer by Magnetic-Assisted Rapid Aptamer Selection (MARAS) (科技部MOST) 2017/8/1~2020/7/31 共同主持人 co-PI
3. 抑制HDAC-FOXM1可提高Sorafenib對肝癌癌幹細胞之毒殺效果 Efficacy of Sorafenib in Liver Cancer Stem Cells is Enhanced by Inhibiting HDAC-FOXM1 Pathway (科技部MOST) 2018/8/1~2019/7/31 共同主持人 co-PI
4. 經由AhR-Jdp2-Nrf2路徑來探討細胞可塑性與氧張力之研究 A Novel Link between Cell Plasticity and Oxygen Tension via the AhR-Jdp2-Nrf2 axis (國衛院NHRI) 2018/1/1~ 2020/12/31 共同主持人co-PI
5. 探討AhR-Nrf2交互作用對於調節幹細胞活性氧化物平衡時所扮演的角色The role of novel crosstalk of AhR-Nrf2 axis to control ROS homeostasis in stem cells (國衛院NHRI) 2015/1/1~ 2017/12/31 共同主持人co-PI
6. 藉JDP2之轉錄來調控細胞防禦作用之離散性和穩固性 Transcriptional control of discreteness and robustness of cellular defense by JDP2 (科技部MOST) 2015/8/1~2017/7/31 共同主持人 co-PI
7. 抑制ATM激酶與五碳糖磷酸途徑以對抗具順鉑抗藥性的癌細胞 Suppression of ATM kinase and pentose phosphate pathway inhibits cisplatin-resistant cancer cells (科技部MOST) 2015/8/1~2016/7/31 主持人 PI
8. 檳榔鹼調控DNA損傷結合蛋白在檳榔相關之口腔癌的角色The role of arecoline regulation of damage-specific DNA binding protein 2 in betel quid-associated oral cavity cancers (國科會NSC) 2013/8/1~ 2014/7/31 主持人PI
9. 探討參與DNA同源重組及核苷酸剪切修補基因在頭頸癌生成及治療上所扮演的角色Exploring the roles of DNA repair genes involved in homologous recombination and nucleotide excision repair in the development and treatment of head and neck cancer (國科會NSC) 2011/8/1~ 2012/7/31 主持人 PI
10. 探討核苷酸剪切修復路徑受檳榔與香菸成分之協同抑制效應並評估其作為頭頸癌生物標誌之潛能Synergistic inhibition of nucleotide excision repair (NER) by arecoline and benze[a]pyrene and evaluation of the use of NER genes as biomarkers for head and neck cancer (國科會NSC) 2010/8/1~ 2012/7/31 共同主持人 co-PI
11. 檳榔鹼調控AURKA及p53表現的機轉，及其對DNA修復，基因體安定性，與頭頸癌發生的影響The roles of arecoline in regulating expressions of AURKA and p53, and in affecting DNA repair and genome stability in head and neck cancer (國科會NSC) 2008/8/1~ 2011/7/31 主持人 PI
12. 頭頸癌幹細胞之DNA修補基因的表現與功能分析The expression and functional analyses of DNA repair genes in head and neck cancer stem-like cells (國科會NSC) 2008/8/1~ 2011/7/31 共同主持人co-PI
代表著作
1. Saito S, Lin YC, Nakamura Y, Eckner R, Wuputra K, Kuo KK, Lin CS*, and Yokoyama K*. (2018) Potential application of cell reprogramming techniques for cancer research. Cellular and Molecular Life Sciences DOI: https://doi.org/10.1007/s00018-018-2924-7
2. Nakade K, Lin CS, Chen XY, Tsai MH, Wuputra K, Zhu ZW, Pan JZ*, Yokoyama KK*. (2017) Jun dimerization protein 2 controls the hypoxia induced replicative senescence via both the p16Ink4a-pRb and Arf-p53 pathways. FEBS Open Bio 7(11):1793-1804.
3. Wu DC, Wang SSW, Liu CJ, Wuputra K, Kato K, Lee YL, Lin YC, Tsai MH, Ku CC, Lin WH, Wang SW, Kishikawa S, Noguchi M, Wu CC, Chen YT, Chai CY, Lin CLS, Kuo KK, Yang YH, Miyoshi H, Nakamura Y, Saito S, Nagata K, Lin CS*, Yokoyama KK*. (2017) Reprogramming antagonizes the oncogenicity of HOXA13-long noncoding RNA HOTTIP axis in gastric cancer cells. Stem Cells 35(10):2115-2128.
4. Pan XY, Tsai, MH, Wuputra K, Ku CC, Lin WH, Lin YC, Kishikawa S, Noguchi M, Saito S, Lin CS*, Yokoyama KK*. (2017) Application of cancer cell reprogramming technology to human cancer research. Anticancer Research 37(7):3367-3377.
5. Kuo KK, Lee KT, Chen KK, Yang YH, Lin YC, Tsai, MH, Wuputra K, Lee YL, Ku CC, Miyoshi H, Nakamura Y, Saito S, Wu CC, Chai CY, Eckner R, Lin CLS, Wang SSW, Wu DC, Lin CS*, Yokoyama KK*. (2016) Positive feedback loop of OCT4 and c-JUN expedites cancer stemness in liver cancer. Stem Cells 34(11): 2613-2624.
6. Wang SSW, Wuputra K, Liu CJ, Lin YC, Chen YT, Chai CY, Lin CLS, Kuo KK, Tsai, MH, Wang SW, Chen KK, Miyoshi H, Nakamura Y, Saito S, Hanafusa T, Wu DC, Lin CS*, Yokoyama KK*. (2016) Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer. Oncotarget 7(24):36049-36064.
7. Huang JL*, Lu HH, Lu YN, Hung PS, Lin YJ, Lin CC, Yang CC, Wong TY, Lu SY, Lin CS*. (2016) Enhancement of the genotoxicity of benzo[a]pyrene by arecoline through suppression of DNA repair in HEp-2 cells. Toxicology In Vitro 33:80-87.
8. Lin CS*, Chiou WY, Kee KW, Chen TF, Lin YJ, Huang JL*. (2016) Xeroderma pigmentosum, complementation group D expression in H1299 lung cancer cells following benzo(a)pyrene-exposure as well as in head and neck cancer patients. Journal of Toxicology and Environmental Health, Part A 79(1):39-47.
9. Klionsky DJ* et al. (Lin CS as a coauthor) (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222.
10. Huang JL*, Lin CS, Chang CC, Lu YN, She YL, Wong TY, Wang YF. (2015) Human JC virus small tumor antigen inhibits nucleotide excision repair and sensitizes cells to DNA damaging agents. Mutagenesis 30 (4): 475-485.
11. Huang JL and Lin CS (2015). Interaction between viral proteins and caretakers — Polyomavirus as a model, Advances in DNA Repair, Prof. Clark Chen (Ed.), ISBN: 978-953-51-2209-8, InTech, DOI: 10.5772/59661.
12. Tanigawa S, Lee CH, Lin CS, Ku CC, Hasegawa H, Qin S, Kawahara A, Korenori Y, Miyamori K, Noguchi M, Lee LH, Lin YC, Lin SCL, Nakamura Y, Jin C, Yamaguchi N, Eckner R, Hou DX*, Yokoyama KK*. (2013) Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis. Cell Death & Disease 4: e921.
13. Lin CS*, Wang YC, Huang JL, Hung CC, Chen YF. (2012) Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells. Oral Oncology 48(11):1152-58.
14. Tsai YS, Lin CS, Chiang SL, Lee CH, Lee KW, Ko YC*. (2011) Areca nut induces miR-23a and inhibits repair of DNA double-strand breaks by targeting FANCG. Toxicological Sciences 123(2):480-90.
15. Wang LT, Lin CS, Chai CY, Liu KY, Chen JY, Hsu SH*. (2011) Functional interaction of Ugene and EBV infection mediates tumorigenic effect. Oncogene 30(26):2921-32.
16. Lee KW, Tsai YS, Chiang FY, Huang JL, Ho KY, Yang YH, Kuo WR, Chen MK, Lin CS*. (2011) Lower mRNA expression of ataxia telangiectasia mutated (ATM) gene predicts poorer outcome in laryngeal and pharyngeal cancers. Annals of Oncology 22(5):1088-93.
17. Tsai YS, Huang JL, Lin CS*. (2011) Application of host cell reactivation in evaluating the effects of anticancer drugs and environmental toxicants on cellular DNA repair activity in head and neck cancer. In Selected Topics in DNA Repair (ISBN 978-953-307-606-5), Chen C (Ed.), InTech, Rijeka, Croatia, pp465-482.
18. Wang YC, Tsai YS, Huang JL, Lee KW, Kuo CC, Wang CS, Huang AM, Chang JY, Jong YJ, Lin CS*. (2010) Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and spindle assembly checkpoint: implication for carcinogenesis. Oral Oncology 46(4): 255-262.
19. Pan SH, Tai CC, Lin CS, Hsu WB, Chou SF, Lai CC, Chen JY, Tien HF, Lee FU, Wang WB*. (2009) Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability. Carcinogenesis 30: 366-375.
20. Tsai YS, Lee KW, Huang JL, Liu YS, Juo SHH, Kuo WR, Chang JG, Lin CS*, Jong YJ*. (2008) Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells. Toxicology 249: 230-237.
21. Lee KW, Tsai CC, Chen YW, Chai CY, Su YC, Kuo WR, Lin CS*. (2007) Positive PET-CT in early inverted papilloma of the maxillary sinus. Journal of Clinical Oncology 25: 4848-4850.
22. Chiou SS, Huang JL, Tsai YS, Chen TF, Lee KW, Juo SHH, Jong YJ, Hung CH, Lin CS*. (2007) Elevated mRNA transcripts of non-homologous end-joining repair genes in pediatric acute lymphoblastic leukemia. Leukemia 21: 2061-2063.