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蔡英美  (Tsai Eing-Mei)

 

 

現任：1.高雄醫學大學研究資源整合發展中心主任

                                 Director,Center for Research Resource and Development,Kaohsiung Medical

                                      University,Kaohsiung.

           2.高雄醫學大學附設醫院婦產部生殖醫學科主任

                       Chief, Division of  Reproductive Medicine, Department of Obstetrics  

                              and Gynecology,Kaohsiung Medical University Hospital,Kaohsiung

Tel：(07)3121101   ext 6446

Email：tsaieing@yahoo.com, tsaieing@kmu.edu.tw

 

 
學歷 高雄醫學大學醫學院醫學研究所醫學博士

PhD, Graduate Institute of Medicine,   Kaohsiung Medical University, Taiwan

 
經歷
  1. 日本京都大學產婦人科胚胎發生研究室研究
  2. 美國MD Anderson Cancer Center, 分子腫癌部訪問學者
  1. Research fellow, Division of Embryologic Development in Department of Obstetrics   and Gynecology, Kyoto University, Japan
  2. Visiting Associate Professor, Department of Molecular & Cellular   Oncology, MD Andersen Caner Center, USA  
專長
  1. 婦產科
  2. 生殖內分泌
  3. 內分泌分子學
  1. Obstetrics and Gynecology
  2. Reproductive Medicine
  3. Endocrinology

 
研究方向
  1. 子宮內膜異位症
  2. 乳癌
  3. 幹細胞
  4. 環境荷爾蒙
  1. Endometriosis
  2. Breast cancer
  3. Stem cell
  4. Environmental hormone

 
執行計畫
  1. 內膜異位症免疫調控因子之促血管新生作用之機制探討 (總主持人)
  2. 探究環境荷爾蒙對乳癌的致病機轉及尋求預防或治療對策 (整合型)
  3. miRNA對於子宮內膜異位症的研究
  1. Study on the Angiogenic Mechanism of   Immunomodulatory Cytokine(s) in the Pathogenesis of Endometriosis. (PI)
  2. The role of endocrine disrupter substance on   breast tumorigenesis and development of novel therapeutic strategies. (PI)
  3. Functional study of miRNA regulation in Endometriosis.

 
代表著作
  1. Hsieh CJ, Kuo PL, Hou MF, Hung   JY, Chang FR, Hsu YC, Huang YF, Tsai   EM, Hsu YL. (2014) Wedelolactone inhibits breast cancer-induced   osteoclastogenesis by decreasing Akt/mTOR signaling. Int J Oncol. 2014 Nov   21. doi: 10.3892/ijo.2014.2769. [Epub ahead of print] (SCI)
  2. Hsu   YL, Tsai EM, Hou MF,   Wang TN, Hung JY, Kuo PL. (2014) Obtusifolin suppresses phthalate   esters-induced breast cancer bone metastasis by targeting parathyroid   hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-11940. (SCI)
  3. Liang   SS*, Wang TN, Tsai EM*. (2014) Analysis of   Protein-Protein Interactions in MCF-7 and MDA-MB-231 Cell Lines Using   Phthalic Acid Chemical. Int J Mol Sci. Nov 13;15(11):20770-20788. (*corresponder: Liang SS and Tsai EM) (SCI) (NSC 102-2632-B-037-001-MY3)
  4. Huang   PC, Li WF, Liao PC, Sun CW, Tsai EM*, Wang SL*. (2014) Risk for   estrogen-dependent diseases in relation to phthalate exposure and   polymorphisms of CYP17A1 and estrogen receptor genes. Environ   Sci Pollut Res Int. Dec;21(24):13964-13973. (*corresponder: Tsai EM and Wang SL) (SCI)(NSC   102-2632-B-037-001-MY3)
  5. Tsai   CF, Hsieh TH, Lee JN, Hsu CY, Wang YC, Lai FJ, Kuo KK, Wu HL, Tsai EM*,   Kuo PL*. (2014) Benzyl butyl   phthalate induces migration, invasion, and angiogenesis of Huh7   hepatocellular carcinoma cells through nongenomic AhR/G-protein*corresponder: Tsai EM and Kuo PL) (SCI) (NSC 102-2628-B-037-011-MY3, NSC 102-2632-B-037-001-MY3)   (KMUH102-2R22, KMUH101-1R27,   KMUH100-0R24)
  6. Cheng   DE, Tsai YM, Hsu YL, Hou MF, Tsai EM, Wang JY, Kan JY, Kuo PL. (2014)Cluster of differentiation 45   activation is crucial in interleukin-10-dependent tumor-associated dendritic   cell differentiation. Oncol Lett. Aug;8(2):620-626. (SCI)
  7. Cheng   DE, Hung JY, Huang MS, Hsu YL, Lu CY, Tsai EM, Hou MF, Kuo PL. (2014) Myosin IIa activation is   crucial in breast cancer derived galectin-1 mediated tolerogenic dendritic   cell differentiation. Biochim Biophys Acta.Jun;1840(6):1965-76.   (SCI) (NSC   102-2632-B-037-001-MY3), (KMUH99-9I04)
  8. Suen   JL, Chang Y, Chiu PR, Hsieh TH, His E, Chen YC, Chen YF, Tsai EM*.   (2014) Serum level of IL-10 is increased in patients with endometriosis, and   IL-10 promotes the Growth of lesions in a murine model. The American Journal of Pathology. Feb;184(2):464-471.(NSC-99-2628-B-037-009-MY3,   NSC 102-2628-B-037-011-MY3), (KMUH101-1R27, KMUH100-0R24, KMUH99-9I04, and   KMUH 99-9R30)
  9. Hsu   CY, Hsieh TH, Tsai CF, Tsai HP, Chen HS, Chang Y, Chuang HY, Lee JN, Hsu YL, Tsai EM*. (2014) miRNA-199a-5p regulates VEGFA in endometrial mesenchymal stem   cells and contributes to the pathogenesis of endometriosis. J Pathol. Feb;232(3):330-343. (SCI) (NSC 102-2628-B-037-011-MY3, NSC   102-2632-B-037-001-MY3), (KMUH99-9I04, KMUH101-1R27, KMUH100-0R24)
  10. Hsieh   CJ, Kuo PL, Hsu YC, Huang YF, Tsai   EM*, Hsu YL*. (2014) Arctigenin, a dietary phytoestrogen, induces   apoptosis of estrogen receptor-negative breast cancer cells through the   ROS/p38 MAPK pathway and epigenetic regulation. Free Radic Biol Med. 67:159-170.   (*corresponder: Tsai EM and Hsu YL) (SCI) (NSC 102-2632-B-037-001-MY3)
  11. Wang   SW, Wang SS, Wu DC, Lin YC, Ku CC, Wu CC, Chai CY, Lee JN, Tsai EM, Lin CL, Yang RC, Ko YC,   Yu HS, Huo C, Chuu CP, Murayama Y, Nakamura Y, Hashimoto S, Matsushima K, Jin   C, Eckner R, Lin CS, Saito S, Yokoyama KK. (2013) Androgen receptor-mediated   apoptosis in bovine testicular induced pluripotent stem cells in response to   phthalate esters. Cell Death Dis. Nov 7;4:e907. (SCI)
  12. Hsu   YL*, Hou MF, Kuo PL, Huang YF, Tsai EM. (2013) Breast tumor-associated   osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/Snail   signaling pathway. Oncogene. Sep 12;32(37):4436-4447.  
  13. Hung   CH, Yang SN, Wang YF, Liao WT, Kuo PL, Tsai EM, Lee CL, Chao YS, Yu HS, Huang SK, Suen JL. (2013)   Environmental alkylphenols modulate cytokine expression in plasmacytoid   dendritic cells. PLoS One. Sep 11;8(9):e73534. (SCI)
  14. Liang   SS, Shiue YL, Kuo CJ, Guo SE, Liao WT, Tsai EM*. (2013)   Online monitoring oxidative products and metabolites of nicotine by free   radicals generation with fenton reaction in tandem mass spectrometry. Scientific   World Journal. Jul 25;2013:189162.
  15. Chen   FM, Ou-Yang F, Yang SF, Tsai EM,   Hou MF. (2013) p53 codon 72 polymorphism in   Taiwanese breast cancer patients. Kaohsiung J Med Sci.   2013 May;29(5):259-264. (SCI)
  16. Tsai   EM,   Wang YS, Lin CS, Lin WY, His E, Wu MT, Juo SH. (2013) A microRNA-520 mirSNP at the MMP2   gene influences susceptibility to endometriosis in Chinese women.   J Hum Genet. Apr;58(4):202-209.
  17. Lee   TY Tony, Tsai CF, Hsieh TH, Jason Chen JJ, Wang YC, Kao MC, Wu RM, Singh S, Tsai   EM*, Lee JN*. (2012) Ectopic Pregnancy-Derived Human Trophoblastic Stem   Cells Regenerate Dopaminergic Nigrostriatal Pathway to Treat Parkinsonian   Rats. PLoS One. 7(12):e52491. (*corresponder: Tsai   EM and Lee JN) (NSC 99-2628-B-037-009-MY3),   (KMUH99-9I04)
  18. Hsieh   TH, Tsai CF, Hsu CY, Kuo PL, Hsi E, Suen JL, Hung CH, Lee JN, Chai CY, Wang   SC, Tsai EM. (2012) n-   Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing   Expression of Lymphoid Enhancer Factor 1. PLoS One. Sep;7(8):e42750.   (NSC 99-2628-B-037-009-MY3)
  19. Wang   YC, Chen HS, Long CY, Tsai CF, Hsieh TH, Hsu CY, Tsai EM. (2012)   Possible mechanism of phthalates-induced tumorigenesis. Kaohsiung   J Med Sci. Jul;28(7 Suppl):S22-7.
  20. Chang CY, Tsai EM, Wu   CH, Wang CL, Liu CM, Long CY. (2012) Pelvic floor abscess secondary to   gossypiboma following a total Prolift procedure. Taiwan J Obstet Gynecol.   Jun;51(2):283-4.
  21. Long CY, Juan YS, Wu MP, Liu   CM, Chiang PH, Tsai EM. (2012) Changes in Female Sexual Function   following Anterior with and without Posterior Vaginal Mesh Surgery for the   Treatment of Pelvic Organ Prolapse. J Sex Med. 9(8):2167-2174.
  22. Hsieh TH, Tsai CF, Hsu CY,   Kuo PL, Lee JN, Chai CY, Hou MF, Chang CC, Ko YC, Tsai EM. (2012) Phthalates stimulate the epithelial to   mesenchymal transition through an HDAC6-dependent mechanism in human breast   epithelial stem cells. Toxicol Sci. Aug;128(2):365-76. (NSC 99-2628-B-037-009-MY3)收錄於Diseases>
  23. Lin KL, Juan YS, Lo   TS, Liu CM, Tsai EM, Long CY. (2012) 3-Dimensional Ultrasonographic   Assessment of the Compression Effect on Urethra Following the Tension-Free   Vaginal Tape and Transobturator Tape Procedures. Ultrasound Obstet Gynecol.   Apr;39(4):452-7.
  24. Chang   Y, Chang Y, Higuchi A, Shih YJ, Li PT, Chen WY, Tsai EM, Hsiue GH.   (2012) Bioadhesive Control of Plasma Proteins and Blood Cells from Umbilical   Cord Bleed onto the Interface Grafted with Zwitterionic Polymer Brushes.   Langmuir. 2012 Jan;28(9):4309-4317.
  25. Hsu   YL, Chen CY, Lin IP, Tsai EM, Kuo PL, Hou MF. (2012) 4-Shogaol, an   Active Constituent of Dietary Ginger, Inhibits Metastasis of MDA-MB-231 Human   Breast Adenocarcinoma Cells by Decreasing the Repression of NF-kB/Snail on   RKIP. J Agric Food Chem. Jan 25;60(3):852-61.
  26. Long   CY, Hsu CS, Wu CH, Liu CM, Wang CL, Tsai EM. (2012) Three-year outcome   of transvaginal mesh repair for the treatment of pelvic organ prolapsed. Eur   J Obstet Gynecol R B. 2012 Mar;161(1):105-108.
  27. Chen   HS, Chiang PH, Wang YC, Kao MC, Shieh TH, Tsai CF, Tsai EM. (2012) Benzyl butyl phthalate induces necrosis by   AhR mediation of CYP1B1 expression in human granulose cells. Reprod Toxicol. Jan;33(1):67-75.
  28. Hsieh TH, Tsai CF,   Hsu CY, Kuo PL, Lee JN, Chai CY, Wang SC, Tsai EM. (2012) Phthalates induce proliferation and   invasiveness of estrogen receptor-negative breast cancer through the   AhR/HDAC6/c-Myc signaling pathway. FASEB J. Feb;26(2):778-87.(NSC 99-2628-B-037-009-MY3)
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