許雅玲 （Ｈsu Ya-Ling）

現任：高雄醫學大學醫學研究所教授
Graduate Institute of Medicine, Kaohsiung Medical University
Professor
Tel：07-3121101 ext 2136-26
Email：yainghsu@kmu.edu.tw

學歷
高雄醫學大學天然藥物研究所
Graduate Institute of Natural Products, Kaohsiung Medical University
藥學博士（Ph. D）

經歷
高雄醫學大學醫學研究所
Graduate Institute of Medicine, Kaohsiung Medical University
助理教授
Assistant Professor

專長
藥理學, 腫瘤學, 細胞分子生物學, 藥效評估
Pharmacology, Molecular cell biology, Oncology, Pharmacological Evaluation

研究方向
腫瘤微環境及相關藥物開發
The investigation of cancer microenvironment and drug development

執行計畫
中草藥抑癌成分調控肺癌微環境內花生四烯酸代謝之研究
肺癌浸潤之樹突細胞對於肺癌轉移之角色探討及相關藥物開發
探究環境荷爾蒙對乳癌的致病機轉及尋求預防或治療對策

代表著作
2013-12
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation.
Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu
Free radical biology and medicine
YL*.
2013-12
Synergistic effect of lung tumor-associated dendritic cell-derived HB-EGF and CXCL5 on cancer progression.
Kuo PL, Huang MS, Hung JY, Chou SH, Chiang SY, Huang YF, Yang CJ, Tsai MJ, Chang WA, Hsu YL*.
International journal of cancer
2013-09
Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/Snail signaling pathway.
Hsu YL*, Hou MF, Kuo PL, Huang YF, and Tsai EM.
Oncogene
2013-06
Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin α6β4 and Notch1/Jagged2 signaling pathway.
Hsu, YL, Wu CY, Hung JY, Lin YS, Huang MS, Kuo PL*.
Carcinogenesis
2013-06
MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein.
Kuo PL, Liao SH, Hung JY, Huang MS, Hsu
Biochimica et biophysica acta-subjects
YL*.
2013-02
Subamolide A induces mitotic catastrophe accompanied by apoptosis in human lung cancer cells.
Hung JY, Wen CW, Hsu YL, Lin ES, Huang MS, Chen CY, Kuo PL*.
Evidence-based complementary and alternative medicine
2012-12
CXCL1/GROα increases cell migration and invasion of prostate cancer by decreasing fibulin-1 expression through NF-κB/HDAC1 epigenetic regulation.
Kuo PL, Shen KH, Hung SH, Hsu YL*.
Carcinogenesis
2012-02
Nonylphenol Induces Bronchial Epithelium Apoptosis via Fas-mediated Pathway and Stimulates Bronchial Epithelium to Secrete IL-6 and IL-8, causing Bronchial Smooth Muscle Proliferation and Migration.
Kuo PL, Hsu YL, Tsai MJ, Lien CT, Huang MS, Ko YC*.
Basic & clinical pharmacology & toxicology
2012-01
4-Shogaol, an Active Constituent of Dietary Ginger, Inhibits Metastasis of MDA-MB-231 Human Breast Adenocarcinoma Cells by Decreasing the Repression of NF-κB/Snail on RKIP.
Hsu YL, Chen CY, Lin IP, Tsai EM, Kuo PL*, Hou MF*.
Journal of agricultural and food chemistry
2011-12
Glabridin inhibits migration, invasion and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting FAK/Rho signaling pathway.
Tsai YM, Yang CJ, Hsu YL, Wu LY, Tsai CY,
Integrative cancer therapies
Hung JY, Lien CT, Huang MS, Kuo PL*.
2011-12
Isolinderanolide B, a butanolide extracted from the stems of Cinnamomum subavenium, inhibits proliferation of T24 human bladder cancer cells via blocking cell cycle progression and inducing apoptosis.
Shen KH, Lin ES, Kuo PL, Chen CY, Hsu YL*.
Integrative cancer therapies
2011-10
Heat shock induces apoptosis through reactive oxygen species involving mitochondrial and death receptor pathways in cornea cells.
Hsu YL, Yu HS, Lin HC, Wu KY, Yang RC, Kuo PL*.
Experimental eye research
2011-10
Lung tumor associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway.
Hsu YL, Huang MS, Yang CJ, Hung JY, Wu LY, Kuo PL*.
Journal of biological chemistry
2011-08
Lung tumor associated dendritic cell-derived amphiregulin increased cancer progression.
Hsu YL, Huang MS, Cheng DE, Hung JY, Yang CJ, Chou
Journal of immunology
SH, Kuo PL*.
2011-07
Pterostilbene Suppresses Benzo[a]pyrene-Induced Airway Remodeling.
Kuo PL, Hsu YL, Tsai MJ, Huang MS*.
Journal of agricultural and food chemistry
2011-05
Bronchial Epithelium-Derived IL-8 and RANTES Increased Bronchial Smooth Muscle Cell Migration and Proliferation by Kruppel-like Factor 5 in Areca Nut-Mediated Airway Remodeling.
Kuo PL, Hsu YL, Huang MS, Chiang SL, Ko YC*.
Toxicological sciences
2011-05
CXCL5/ENA78 increased cell migration and epithelial-to-mesenchymal transition of hormone-independent prostate cancer by early growth response-1/snail signaling pathway.
Kuo PL, Chen YH, Chen TC, Shen KH, Hsu YL*.
Journal of cellular physiology
2011-05
Signalling pathway of isophorone diisocyanate-responsive interleukin-8 in airway smooth muscle cells.
Kuo PL, Huang MS, Huang SK, Ni WC, Hung JY, Ko YC, Hung CH, Tsai YM, Duh TH, Hsu YL*.
European respiratory journal
2011-04
Ginger suppresses phthalate ester-induced airway
Kuo PL, Hsu YL,
Journal of agricultural
remodeling.
Huang MS, Tsai MJ, Ko YC*.
and food chemistry
2011-03
α-Mangostin, a dietary xanthone, induces autophagic cell death by activating the AMP-activated protein kinase pathway in glioblastoma cells.
Chao AC, Hsu YL, Liu CK, Kuo PL*.
Journal of agricultural and food chemistry
2011-02
Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway.
Hsu YL, Wu LY, Hou MF, Tsai EM, Lee JN, Liang HL, Jong YJ, Hung CH, Kuo PL*.
Molecular nutrition & food research
2011-02
Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway.
Kuo PL, Hung JY, Huang SK, Chou SH, Cheng DE, Jong YJ, Hung CH, Yang CJ, Tsai YM, Hsu YL*, Huang MS*.
Journal of immunology
2010-12
Tricetin, a Dietary Flavonoid, Induces Apoptosis through the Reactive Oxygen Species/c-Jun NH(2)-Terminal Kinase Pathway in Human Liver Cancer Cells.
Hsu YL, Hou MF, Tsai EM, Kuo PL*.
Journal of agricultural and food chemistry
2010-09
6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells.
Hsu YL, Chen CY, Hou MF, Tsai EM, Jong YJ, Hung CH, Kuo PL*.
Molecular nutrition & food research
2010-07
Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis.
Wang CC, Chiang YM, Praseuth MB, Kuo PL, Liang HL, Hsu YL*.
Basic & clinical pharmacology & toxicology
2010-06
Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo.
Hung JY, Hsu YL, Ko YC, Tsai YM, Yang CJ, Huang MS, Kuo PL*.
Lung cancer
2010-06
Oxidative and endoplasmic reticulum stress signaling are involved in
Hung JY, Hsu YL, Ni
Lung cancer
dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells.
WC, Tsai YM, Yang CJ, Kuo PL*, Huang MS*.